Short Course: Drug Transporters in ADME

Sunday 21 May 2017
Stockholmsmässan : K13

Introduction words to this short course:

The course will deal with the role of membrane transport proteins in determining the ADME properties of drug candidates and substances. We will give an overview of drug-transporters in barrier tissues, with emphasis on transporters that mediate intestinal absorption/efflux and drug disposition to the brain (transporters in the blood brain barrier).  Lectures will cover basic concepts such as flux, permeability, barrier tissue biology, transporter kinetics and transporter structure and function. This will be supplemented with a description of the in vitro methods for studying drug transport/transporters in tissue models. Finally, we will present the EMEA/FDA-guidelines for investigating transporter interactions and discuss how this may be integrated in a drug development context. 

07:00 – 08:00 Breakfast

08:00 Opening

08:00 – 09:00 Overview of transporters and organs relevant to determining ADME properties of drug compounds
Presenter: Carsten Uhd Nielsen

09:00 – 10:00 Basic transporter kinetics and barrier tissues.
Presenter: Birger Brodin

10:00 – 10:30 COFFEE

10:30 – 11:30 Advanced transporter kinetics, multiple transporters
Presenter: Bente Steffansen

11:30 – 12:30 Intestinal transport, models to study transport and transporters
Presenter: Carsten Uhd Nielsen

12:30 – 13:00 LUNCH

13:00 – 14:00 The role of transporters at the blood brain barrier; uptake and efflux mechanisms
Presenter: Birger Brodin

14:00 – 15:00 Regulatory aspects of drug transporters
Presenter: Bente Steffansen